Use of pgam2 in breeding of blcattle black cattle
AssigneeQingdao Agricultural University
InventorsYajuan DONG, Xiuyuan WANG, Ruili LIU
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AssigneeQingdao Agricultural University
InventorsYajuan DONG, Xiuyuan WANG, Ruili LIU
Estimating the term…
Provided is use of PGAM2 in the breeding of Blcattle black cattle, which belongs to the technical field of molecular biological breeding, in which individuals having a high PGAM2 content are screened as high-quality breeding bulls. In the present disclosure, it is proved by means of experiments that PGAM2 may promote the proliferation and glycolytic metabolism of Sertoli cells to produce lactic acid, an energy substrate required for spermatogenic cell development. It regulates the formation of blood-testis barrier and facilitates the communication between Sertoli cells and germ cells, thereby promoting spermatogenesis. The present disclosure provides a new direction for the breeding of Blcattle black cattle for high quality beef production.
A method for breeding Blcattle black cattle, comprising overexpressing phosphoglycerate mutase 2 (PGAM2) gene in breeding cattle or breeding cattle testis tissue with drugs or genetic engineering methods.
An engineered bovine somatic cell, wherein the engineered bovine somatic cell is a bovine Sertoli cell in which PGAM2 gene is knocked down, knocked out, or overexpressed.
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