Method for producing nonhuman primate animal model of cerebral infarction and pharmaceutical composition for treatment of cerebral infarction
AssigneeAstellas Pharma Inc.
InventorsSoichiro NAKAHARA, Masashi MAEDA
Life of this patent
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Abstract
The present invention relates to a method for producing a nonhuman primate animal model of cerebral infarction, comprising administering endothelin to basal ganglia and thalamic region of a nonhuman primate, and thereby inducing basal ganglia damage, thalamus damage, and internal capsule damage; and a pharmaceutical composition for the treatment of cerebral infarction at a subacute to chronic stage, penetrating branch infarction, or cerebral infarction having brain damage in a penetrating branch territory, comprising a NeuroD1 protein or a polynucleotide encoding the NeuroD1 protein.
Claims21
-126. (canceled)
A method for treating penetrating branch infarction, cerebral infarction having brain damage in a penetrating branch territory, or cerebral infarction at a subacute to chronic stage, comprising the step of administering a NeuroD1 protein, or a polynucleotide encoding the NeuroD1 protein to a subject.
A method for producing a nonhuman primate animal model of cerebral infarction, comprising administering endothelin to basal ganglia and thalamic region of a nonhuman primate, and thereby inducing basal ganglia damage, thalamus damage, and internal capsule damage.
Dependencies are inferred from the claim text.