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US 2026/0056093 A1Published application
Sampling system
AssigneeHelia BioMonitoring B.V.
InventorsRafiq Milan LUBKEN, Stijn Robert René HAENEN, Menno Willem José PRINS
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Abstract
A sampling system measures an analyte of interest present in a system of interest, wherein the analyte of interest is included in a medium, e.g., a fluid or another viscoelastic material. The sampling system includes a three-way junction, an inlet channel, an outlet channel, a measurement channel and a measurement chamber. A multiplexed sampling system includes two or more sampling systems. A method for measuring an analyte of interest present in a medium includes using the sample system.
Claims16
A sampling system for measuring an analyte of interest present in a system of interest, wherein the analyte of interest is comprised in a medium, and wherein the analyte of interest has an analyte concentration in the medium, wherein the sampling system comprises:
- a three-way junction connected to an inlet channel, an outlet channel, and a measurement channel, wherein the measurement channel is provided between the three-way junction and a measurement chamber, and wherein the inlet channel is connected or connectable to the system of interest;
- a measurement system for measuring the analyte of interest in the medium in the measurement chamber;
- a waste channel connected to the measurement chamber;
- a medium transport system for causing a flow of medium from the inlet channel, through the three-way junction, to the outlet channel, and for separately causing a flow of medium from the three-way junction, through the measurement channel and the measurement chamber, to the waste channel;
- and
- a control system operatively connected to the measurement system and the medium transport system for controlling the measurement system and the medium transport system,
- wherein the control system is configured to, when the inlet channel is connected to the system of interest:
- operate the medium transport system to facilitate a primary phase for a duration of the primary phase, wherein the medium transport system is operated to cause a flow of medium from the inlet channel, through the three-way junction, to the outlet channel;
- operate the medium transport system to facilitate a secondary phase for a duration of the secondary phase, independent of the primary phase, wherein the measurement system is operated to perform a measurement on the analyte of interest present in the medium in the measurement chamber;
- and
- operate the medium transport system to facilitate a tertiary phase for a duration of the tertiary phase, wherein the medium transport system is operated to cause a flow of medium from the three-way junction, through the measurement channel and the measurement chamber, to the waste channel,
- wherein the duration of the primary phase is longer than a first effective characteristic time which is a time required for the medium transport system in the primary phase to transport a sample of the system of interest, from the system of interest to the three-way junction,
- wherein the duration of the secondary phase is shorter than a second effective characteristic time which is a time in which a sample in the measurement chamber is substantially independent from a sample in the three-way junction, and
- wherein the duration of the tertiary phase is longer than a third effective characteristic time which is a time required for the medium transport system in the tertiary phase to transport a sample of the system of interest, from the three-way junction to the measurement chamber.
11 more elements
A method for measuring an analyte of interest present in a system of interest, wherein the analyte of interest is comprised in a medium and wherein the analyte of interest has an analyte concentration in the medium, wherein use is made of a sampling system comprising:
- a three-way junction connected to an inlet channel, an outlet channel, and a measurement channel, wherein the measurement channel is provided between the three-way junction and a measurement chamber, and wherein the inlet channel is connected or connectable to the system of interest;
- a measurement system for measuring the analyte of interest in the medium in the measurement chamber;
- a waste channel connected to the measurement chamber;
- a medium transport system for causing a flow of medium from the inlet channel, through the three-way junction, to the outlet channel, and for separately causing a flow of medium from the three-way junction, through the measurement channel and the measurement chamber, to the waste channel;
- and
- a control system operatively connected to the measurement system and the medium transport system for controlling the measurement system and the medium transport system,
- wherein the control system is configured to, when the inlet channel is connected to the system of interest;
- operate the medium transport system to facilitate a primary phase for a duration of the primary phase, wherein the medium transport system is operated to cause a flow of medium from the inlet channel, through the three-way junction, to the outlet channel;
- operate the medium transport system to facilitate a secondary phase for a duration of the secondary phase, independent of the primary phase, wherein the measurement system is operated to perform a measurement on the analyte of interest present in the medium in the measurement chamber;
- and
- operate the medium transport system to facilitate a tertiary phase for a duration of the tertiary phase, wherein the medium transport system is operated to cause a flow of medium from the three-way junction, through the measurement channel and the measurement chamber, to the waste channel,
- wherein the duration of the primary phase is longer than a first effective characteristic time which is a time required for the medium transport system in the primary phase to transport a sample of the system of interest, from the system of interest to the three-way junction,
- wherein the duration of the secondary phase is shorter than a second effective characteristic time which is a time in which a sample in the measurement chamber is substantially independent from a sample in the three-way junction, and
- wherein the duration of the tertiary phase is longer than a third effective characteristic time which is a time required for the medium transport system in the tertiary phase to transport a sample of the system of interest, from the three-way junction to the measurement chamber.
11 more elements
Dependencies are inferred from the claim text.