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US 2026/0055443 A1Published application
Imaging system hardware
Assignee10x Genomics, Inc.
InventorsAugusto Manuel Tentori, Rajiv Bharadwaj, Felice Alessio Bava
Life of this patent
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Abstract
A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned.
Claims26
(canceled)
A device comprising:
- a first member comprising a first surface configured to support a first substrate comprising a sample region;
- a first retaining mechanism configured to retain the first substrate on the first surface of the first member;
- a second member comprising a second surface configured to support a second substrate;
- a second retaining mechanism configured to retain the second substrate on the second surface of the second member;
- and
- an alignment mechanism connecting the first member and the second member,
- wherein the alignment mechanism is configured to allow relative movement of the first member and the second member between an open configuration and a closed configuration,
- wherein at least one of the first member or the second member comprises an aperture, and
- wherein the first member, the second member, and the alignment mechanism are arranged such that, in the closed configuration:
- the first surface is substantially parallel to and faces the second surface;
- the first surface is disposed at a distance from the second surface;
- the first substrate is disposed at a distance from the second substrate when the first substrate is retained on the first surface and the second substrate is retained on the second surface;
- and
- the aperture is aligned with the sample region of the first substrate when the first substrate is retained on the first surface.
11 more elements
A device comprising:
- a first member comprising:
- a first surface configured to support a first substrate comprising a sample region, and
- first means for retaining the first substrate on the first surface;
- a second member comprising:
- a second surface configured to support a second substrate, and
- second means for retaining the second substrate on the second surface;
- and
- an alignment mechanism connecting the first member and the second member, wherein:
- the alignment mechanism is configured to allow relative movement of the first member and the second member between an open configuration and a closed configuration,
- at least one of the first member or the second member comprises an aperture, and
- the first member, the second member, and the alignment mechanism are arranged such that, in the closed configuration:
- the first surface is substantially parallel to and facing the second surface;
- the first surface is disposed at a distance from the second surface;
- and
- the first substrate is disposed at a distance from the second substrate when the first substrate is retained on the first surface and the second substrate is retained on the second surface;
- and
- the aperture is aligned with the sample region of the first substrate when the first substrate is retained on the first surface.
14 more elements
Dependencies are inferred from the claim text.