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US 2026/0055153 A1Published application
Development and Use of Novel Interleukin 15 Mutant Polypeptide
AssigneeSuzhou Forlong Biotechnology Co., Ltd.
InventorsEn Ji, Chunyu Wang
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Abstract
Provided in the present application are an IL-15 mutant polypeptide, and a preparation method therefor and the use thereof. Further provided are a nucleic acid encoding the IL-15 mutant polypeptide, a vector containing the nucleic acid, and a host cell.
Claims20
An interleukin-15 (IL-15) mutant polypeptide, comprising the amino acid sequence as set forth in SEQ ID NO:
- 1, wherein:
- X1 is selected from any amino acid of A and N;
- X2 is selected from any amino acid of S, D and Y;
- X3 is selected from any amino acid of D and F;
- X4 is selected from any amino acid of D, G and N;
- X5 is selected from any amino acid of E and Y;
- X6 is selected from any amino acid of I, Q and K;
- X7 is selected from any amino acid of N and Y;
- X8 is selected from any amino acid of Q, S, F and A;
- X9 is selected from any amino acid of M and H;
- and
- X10 is selected from any amino acid of I, A and H;
- wherein the mutant polypeptide has increased or decreased binding activity for IL-15Rβ/γ compared to the naturally occurring IL-15 amino acid sequence.
10 more elements
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Dependencies are inferred from the claim text.