Intracellular cx3cl1 domain peptides and uses thereof

Abstract

Described is a polypeptide including the intracellular domain of CX3CL1 (CX3CL1-ICD), including an amino acid sequence that is at least 90% identical to SEQ ID NO: 1 and pharmaceutical compositions including the above-described polypeptide and a pharmaceutically acceptable excipient. Also included are nucleic acids expressing the polypeptides and expression cassettes and vectors comprising the nucleic acids. The polypeptides can be used in methods of treating a subject exhibiting a symptom of a neurodegenerative disease and/or diagnosed with a neurodegenerative disease and methods of treating a subject exhibiting a symptom of diabetes and/or diagnosed with diabetes comprising administering to the subject the pharmaceutical composition described herein.

Dependencies are inferred from the claim text.