Novel substituted benzothiophene-6-carboxylic acid derivatives, processes for their preparation and therapeutic uses thereof

A compound of the formula (I) or a pharmaceutically acceptable salt thereof:

• wherein:
• R1 and R2 independently represent a hydrogen atom or a deuterium atom;
• R3′ and R3″ independently represent a hydrogen atom, a methyl group, a methoxy group, a chlorine atom, a fluorine atom, or a cyano group;
• R4 represents a hydrogen atom or a fluorine atom;
• R5 and R5′ independently represent a hydrogen atom or a fluorine atom;
• Y represents —CH2—, —CH═, —CR8=, —O— or —NH—, wherein R8 represents a fluorine atom or a (C1-C3)alkyl group;
• represents a single bond or a double bond;
• p is 0 or 1;
• X represents —CH═, —N═ or —CR″═, wherein R″ represents a (C1-C3)alkyl group or a halogen atom, such as a fluorine or a chlorine atom, a cyano group, or a (C1-C3)fluoroalkyl group, such as a trifluoromethyl;
• R7 independently represents a (C1-C3)alkyl group, such as a methyl group, a halogen atom, such as a fluorine atom, a cyano group, or a (C1-C3)fluoroalkyl group, such as a trifluoromethyl;
• n is 0, 1 or 2;
• and
• R6 represents a (C6-C10)aryl group or a 5- or 6-membered heteroaryl group,
• said (C6-C10)aryl group or a 5- or 6-membered monocyclic heteroaryl group being optionally substituted with 1 to 3 groups selected from —Z—R6a and R6a;
• wherein
• Z is methylene;
• R6a is selected from
• a —OH group,
• a (C1-C6)alkyl group optionally substituted by a cyano group or a —OH group,
• a (C1-C6)alkylene group,
• a halogen atom,
• a nitro group,
• a cyano group,
• a (C1-C6)fluoroalkyl group,
• a (C1-C6)fluoroalkoxy group,
• a (C3-C6)cycloalkyl group,
• a (C1-C6)alkoxy group,
• a —SF5 group,
• a trifluoromethylsulfonyl group,
• a (C1-C4)alkylthio group;
• a (C1-C4)fluoroalkylthio group,
• a (C1-C4)alkylsulfonyl group
• a —NR9R10 group,
• a —C(O)R9 group,
• a (C3-C7)cycloalkyl group, and
• a 4-7 membered saturated, unsaturated or partially saturated ring containing one to four heteroatoms or groups selected from O, NH, C(O) and S(O)0-2;
• wherein R9 and R10 are independently selected from a hydrogen atom and a (C1-C4)alkyl group;
• or R9 and R10 together with the nitrogen to which they are both attached form a 4 to 7 member saturated ring containing one other heteroatom or group selected from O, NH, and S(O)0-2;
• wherein said 4-7 member ring can be unsubstituted or substituted with a (C1-C4)alkyl group.