Heterocyclic compound, method for preparing same, and pharmaceutical use thereof

A compound represented by general formula (I) or a pharmaceutically acceptable salt thereof:

• wherein:
• ring A is phenyl or 6-membered heteroaryl;
• each RA is identical or different and is independently selected from the group consisting of a deuterium atom, halogen, hydroxy, cyano, alkyl, alkoxy, haloalkyl, haloalkoxy, hydroxyalkyl, hydroxyalkoxy, alkoxyalkyl, alkenyl, alkynyl, —NR3R4, -alkylene-NR3R4, —O-alkylene-NR3R4, —C(═NR5)R6, —S(O)vNR3R4, —NR5S(O)vR6, —S(O)vR6, —S(═NR5)(O)R6, —NR5C(O)R6, —NR5C(O)NR3R4, —C(O)NR5—OR6, —P(O)R7R8, —C(O)NR5—NR3R4, —C(═NR5)NR5—OR6, —C(O)NR5-alkylene-Cy, —C(═NR5)NR3R4, —C(O)—C(O)—NR3R4, —S(═NR5)NR3R4, —S(═NR5)R6, —S(═NR5)(O)NR3R4, —Si(O)NR3R4, —Si(R6)3, —OR6, cycloalkyl, heterocyclyl, aryl, heteroaryl, cycloalkylalkyl, heterocyclylalkyl, —C(O)-cycloalkyl, —C(O)-heterocyclyl, -alkylene-O-alkylene-cycloalkyl, -alkylene-O-cycloalkyl, —O-alkylene-heteroaryl, and —O-alkylene-heterocyclyl, wherein the alkyl, alkoxy, alkoxyalkyl, alkenyl, alkynyl, alkylene, cycloalkyl, heterocyclyl, aryl, heteroaryl, cycloalkylalkyl, and heterocyclylalkyl are each independently and optionally substituted with one or more R01;
• Cy is cycloalkyl or heterocyclyl, and the cycloalkyl and heterocyclyl are each independently and optionally substituted with one or more substituents selected from the group consisting of a deuterium atom, halogen, hydroxy, cyano, oxo, amino, —NH alkyl, —N(alkyl)2, acetyl, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl;
• each R3, R4, and R5 is identical or different and is independently selected from the group consisting of a hydrogen atom, alkyl, deuterated alkyl, alkoxy, deuterated alkoxy, alkenyl, alkynyl, NR20R21, C(O)NR20R21, NR22C(O)R23, C(O)R23, C(O)OR23, OC(O)R23, S(O)vR23, S(O)vOR23, OS(O)vR23, S(O)vNR20R21, OR23, cycloalkyl, heterocyclyl, aryl, and heteroaryl, wherein the alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl are each independently and optionally substituted with one or more R01;
• alternatively, R3 and R4, together with the nitrogen atom to which they are attached, form heterocyclyl;
• the heterocyclyl is optionally substituted with one or more R01;
• each R6, R7, and R8 is identical or different and is independently selected from the group consisting of a hydrogen atom, alkyl, alkoxy, haloalkyl, deuterated alkyl, haloalkoxy, deuterated alkoxy, hydroxyalkyl, alkenyl, alkynyl, NR20R21, C(O)NR20R21, NR22C(O)R23, C(O)R23, C(O)OR23, OC(O)R23, S(O)vR23, S(O)vOR23, OS(O)vR23, S(O)vNR20R21, OR23, cycloalkyl, heterocyclyl, cycloalkylalkyl, heterocyclylalkyl, aryl, and heteroaryl;
• wherein the alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, cycloalkylalkyl, heterocyclylalkyl, aryl, and heteroaryl are each independently and optionally substituted with one or more R01;
• each R01 is identical or different and is independently selected from the group consisting of a deuterium atom, halogen, hydroxy, cyano, oxo, amino, —NH alkyl, —N(alkyl)2, acetyl, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, =CR7aR8a, —NR3R4, -alkylene-NR3R4, —O-alkylene-NR3R4, —C(═NR5)R6, —S(O)vNR3R4, —NR5S(O)vR6, —S(O)vR6, —S(═NR5)(O)R6, —NR5C(O)R6, —NR5C(O)NR3R4, —C(O)NR5—OR6, —P(O)R7R8, —C(O)NR5—NR3R4, —C(═NR5)NR5—OR6, —C(O)NR5-alkylene-Cy, —C(═NR5)NR3R4, —C(O)—C(O)—NR3R4, —S(═NR5)NR3R4, —S(═NR5)R6, —S(═NR5)(O)NR3R4, —Si(O)NR3R4, —OR6, —Si(R6a)3, —O-alkylene-heteroaryl, and —O-alkylene-heterocyclyl;
• wherein the alkyl, alkenyl, alkynyl, alkoxy, alkylene, cycloalkyl, heterocyclyl, aryl, and heteroaryl are each independently and optionally substituted with one or more substituents selected from the group consisting of a deuterium atom, halogen, hydroxy, cyano, oxo, amino, —NH alkyl, —N(alkyl)2, acetyl, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl;
• each R6a, R7a, and R8a is identical or different and is independently selected from the group consisting of a hydrogen atom, a deuterium atom, halogen, hydroxy, cyano, amino, —NH alkyl, —N(alkyl)2, acetyl, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl;
• R′ is selected from the group consisting of a hydrogen atom, alkyl, haloalkyl, deuterated alkyl, alkoxy, deuterated alkoxy, hydroxyalkyl, cycloalkyl, and heterocyclyl;
• X is O or S;
• Ra and Rb are identical or different and are each independently selected from the group consisting of a hydrogen atom, a deuterium atom, halogen, hydroxy, cyano, amino, alkyl, deuterated alkyl, alkenyl, alkynyl, alkoxy, deuterated alkoxy, haloalkyl, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, cycloalkyloxy, and heterocyclyloxy;
• wherein the alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, cycloalkyloxy, and heterocyclyloxy are optionally substituted with one or more R02;
• with the proviso that Ra and Rb are not simultaneously hydrogen;
• Rc and Rd are identical or different and are each independently selected from the group consisting of a hydrogen atom, a deuterium atom, halogen, hydroxy, cyano, amino, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, deuterated alkyl, haloalkoxy, deuterated alkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, cycloalkyloxy, and heterocyclyloxy;
• wherein the alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, cycloalkyloxy, and heterocyclyloxy are optionally substituted with one or more R02;
• alternatively, Ra and Rb, together with the carbon atom to which they are attached, form cycloalkyl or heterocyclyl;
• alternatively, Rc and Rd, together with the carbon atom to which they are attached, form cycloalkyl or heterocyclyl;
• wherein the cycloalkyl or heterocyclyl is independently and optionally substituted with one or more R02;
• Re is selected from the group consisting of a hydrogen atom, a deuterium atom, halogen, hydroxy, cyano, amino, alkyl, alkoxy, haloalkyl, haloalkoxy, deuterated alkyl, deuterated alkoxy, and hydroxyalkyl;
• each R02 is identical or different and is independently selected from the group consisting of a deuterium atom, halogen, hydroxy, cyano, oxo, amino, an amide group, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl;
• each R20, R21, and R22 is identical or different and is independently selected from the group consisting of a hydrogen atom, alkyl, deuterated alkyl, alkoxy, deuterated alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl;
• wherein the alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl are each independently and optionally substituted with one or more groups selected from the group consisting of a deuterium atom, halogen, hydroxy, cyano, amino, alkyl, alkoxy, haloalkyl, haloalkoxy, and hydroxyalkyl;
• each R23 is identical or different and is independently selected from the group consisting of a hydrogen atom, alkyl, deuterated alkyl, alkoxy, deuterated alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl;
• wherein the alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl are each independently and optionally substituted with one or more groups selected from the group consisting of a deuterium atom, halogen, hydroxy, cyano, amino, alkyl, alkoxy, haloalkyl, haloalkoxy, and hydroxyalkyl;
• X1 is CRX1 or N;
• X2 is CRX2 or N;
• X3 is CRX3 or N;
• X4 is CRX4 or N;
• X5 is CRX5 or N;
• with the proviso that X1, X2, X3, X4, and X5 are not simultaneously N;
• RX1, RX2, RX3, RX4, and RX5 are identical or different and are each independently selected from the group consisting of a hydrogen atom, a deuterium atom, halogen, hydroxy, cyano, amino, an amide group, nitro, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, deuterated alkyl, haloalkoxy, deuterated alkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, —O—(CH2)n-cycloalkyl, —O—(CH2)s-heterocyclyl, aryl, and heteroaryl, wherein the alkyl, alkoxy, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl are each independently and optionally substituted with one or more R03;
• each R03 is identical or different and is independently selected from the group consisting of a deuterium atom, halogen, hydroxy, cyano, oxo, amino, an amide group, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl;
• each v is identical or different and is independently selected from the group consisting of 0, 1, and 2;
• n is selected from the group consisting of 0, 1, 2, 3, 4, and 5;
• s is selected from the group consisting of 0, 1, 2, 3, 4, and 5;
• and
• r is selected from the group consisting of 0, 1, 2, 3, 4, and 5;
• with the proviso that
• is not