Phthalazinone compounds as parp7 inhibitors

A compound or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein the compound is of Formula IV:

• wherein:
• X1 is selected from the group of —N— and —CR4a2—;
• X2 is selected from the group of —N— and —CR4a4—;
• R4a1, R4a2, R4a3, and R4a4 are independently selected from the group of H, halo, —OH, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —O—C1-6alkyl, —O—C2-6alkenyl, —O—C2-6alkynyl, —O-cycloalkyl, —O-heterocyclyl, —O-aryl, —O-heteroaryl, —SO2-cycloalkyl, —NR4L1R4L2, and C2-6alkynyl-NR4L3R4L4;
• wherein if X1 is —CR4a2— and X2 is —CR4a4—, then at least one of R4a1, R4a2, R4a3, and R4a4 is not H;
• wherein each C1-6alkyl, C2-6alkenyl, C2-6alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —O—C1-6 alkyl, —O—C2-6alkenyl, —O—C2-6alkynyl, —O-cycloalkyl, —O-heterocyclyl, —O-aryl, —O-heteroaryl, or —SO2-cycloalkyl of R4a1, R4a2, R4a3, and R4a4 is unsubstituted or substituted with one or more substituents independently selected from the group consisting of halo, —OH, —CN, C1-6alkyl, C1-6haloalkyl, cycloalkyl, halocycloalkyl, —O—C1-6alkyl, and —C(O)NH2;
• R4L1, R4L2, R4L3, and R4L4 are independently selected from the group of H, C1-6alkyl, C2-6alkynyl, and cycloalkyl, wherein each C1-6alkyl, C2-6alkynyl, or cycloalkyl of R4L1, R4L2, R4L3, and R4L4 is unsubstituted or substituted with one or more substituents independently selected from the group consisting of halo, C1-6alkyl, C1-6haloalkyl, cycloalkyl, and halocycloalkyl;
• X3 is selected from the group of —O—, —NR4b1—, and —CR4b2R4b3—, wherein R4b1, R4b2, and R4b3 are independently selected from the group of H and C1-6alkyl;
• A4 is selected from the group of
• wherein a bond marked 1A is to X3;
• X10 is selected from the group of —N— or —CR4c1—, X11 is —N— and —CR4c2—, and X12 is selected from the group of —N— and —CR4c4—;
• R4c1, R4c2, R4c3, R4c4, R4c5, R4c6, R4c7, and R4c8 are independently selected from the group of H, halo, —CN, —SO2CH3, —SO2NH2, and —NHSO2CH3;
• B4 is selected from the group of a 3 to 8-membered monocyclic heterocyclediyl, a 7 to 18-membered polycyclic heterocyclediyl, and a 7 to 18-membered spirocyclic heterocyclediyl;
• wherein the 3 to 8-membered monocyclic heterocyclediyl, 7 to 18-membered polycyclic heterocyclediyl, or 7 to 18-membered spirocyclic heterocyclediyl of B4 is unsubstituted or substituted with one or more substituents selected from the group consisting of halo, C1-6alkyl, and oxo;
• provided that B4 is not
• D4 is selected from the group of C1-6alkyl, cycloalkyl, aryl, heteroaryl, —O—C1-6alkyl, —O-aryl, —O-heteroaryl, —C(O)—C1-6alkyl, —C(O)-cycloalkyl, —C(O)-heterocyclyl, —C(O)-aryl, —C(O)-heteroaryl, —N(R4D1)(R4D2), —C(O)N(R4D3)(R4D4), and —N(R4D5)C(O)R4D6;
• wherein the C1-6alkyl, cycloalkyl, aryl, heteroaryl, —O—C1-6alkyl, —O-aryl, —O-heteroaryl, —C(O)—C1-6 alkyl, —C(O)-cycloalkyl, —C(O)-heterocyclyl, —C(O)-aryl, or —C(O)-heteroaryl of D4 is unsubstituted or substituted with one or more substituents selected from the group consisting of halo, —CN, C1-6alkyl, C1-6haloalkyl, cycloalkyl, —OH, —O—C1-6alkyl, C1-6alkyl-OH, —O—C1-6haloalkyl, C1-6alkyl-O—C1-6alkyl, C1-6alkyl-O—C1-6haloalkyl, —C(O)-cycloalkyl, and —C(O)N(R4D10)2, wherein each R4D10 is independently selected from the group of H and C1-6alkyl;
• R4D1, R4D3, and R4D5 are independently selected from the group of H and C1-6alkyl;
• R4D2 is selected from the group of aryl and heteroaryl, wherein the aryl or heteroaryl of R4D2 is unsubstituted or substituted with one or more substituents selected from the group consisting of halo, —CN, C1-6alkyl, C1-6haloalkyl, cycloalkyl, —OH, —O—C1-6alkyl, —O—C1-6haloalkyl, C1-6alkyl-O—C1-6alkyl, C1-6 alkyl-O—C1-6haloalkyl, —C(O)-cycloalkyl, and —C(O)N(R4D11)2, wherein each R4D11 is independently selected from the group of H and C1-6alkyl;
• and
• R4D4 and R4D6 are independently selected from the group of C1-6alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein each C1-6alkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl of R4D4 and R4D6 is unsubstituted or substituted with one or more substituents independently selected from the group consisting of halo, —CN, C1-6alkyl, C1-6haloalkyl, cycloalkyl, —OH, —O—C1-6alkyl, —O—C1-6haloalkyl, C1-6alkyl-O—C1-6alkyl, C1-6alkyl-O—C1-6haloalkyl, —C(O)-cycloalkyl, and —C(O)N(R4D12)2, wherein each R4D12 is independently H or C1-6alkyl;
• provided that if B4 is
• and D4 is —CHF2, —CF2CH3, or —CF2CF3, then R4a2 is not F, if X3 is —O—, B4 is
• and D4 is —C(O)-aryl, then R4a4 is not Cl, and if D4 is
• and R4c2 is F, then R4a2 is not F.