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AssigneeAdama Makhteshim Ltd.
InventorsGal SUEZ, Leonid METSGER, Artur ULIKOWSKI, Tomasz JASTRZABEK, Rafal LISIAK, Jie LI
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The present invention relates to the preparation of cyantraniliprole, comprising the preparation of 8-methyl-2,4-dioxo-1,4-dihydro-2H-benzo[d][1,3]oxazine-6-carbonitrile key intermediate via 2-amino-5-((hydroxyimino)methyl)-3-methylbenzoic acid. Wherein hydroxylamine attacks a benzylic formyl group, to obtain the 2-amino-5-((hydroxyimino)methyl)-3-methylbenzoic acid, that undergoes simultaneously or by consecutive steps dehydrogenation and cyclization to obtain the benzo[d][1,3]oxazine group and the cyano group of the desired product. In addition, an improved method for the synthesis of the benzylic formyl group is also displayed.
A process for preparing of a compound of formula (I), or its salts thereof
A process of preparing of a compound of formula (IV), and its salt thereof,
A process of preparing of a compound of formula (II), and its salt thereof,
A process of preparing of a compound of formula (VIII), and its salt thereof,
Dependencies are inferred from the claim text.