Flow cell patterning methods with functionalized nanoparticles
AssigneeIllumina, Inc.
InventorsTyler Dill, Robert Yang
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Abstract
In a method of preparing a flow cell, a slot die coater is used to introduce a nanoparticle suspension at a continuous flow rate to a substrate surface including depressions separated by interstitial regions, which generates a layer of the nanoparticle suspension at a stable concentration across the substrate surface. During the introduction of the nanoparticle suspension, at least some functionalized nanoparticles within the layer respectively enter at least some of the depressions. An excess amount of the layer is removed from the interstitial regions.
Claims14
A method of preparing a flow cell, comprising:
- using a slot-die coater at a continuous flow rate, introducing a nanoparticle suspension to a substrate surface including depressions separated by interstitial regions, thereby generating a layer of the nanoparticle suspension at a stable concentration across the substrate surface, whereby at least some functionalized nanoparticles within the layer respectively enter at least some of the depressions;
- and
- removing an excess amount of the layer from the interstitial regions.
A method of preparing a flow cell, comprising:
- using a slot-die coater, introducing a nanoparticle suspension to a substrate surface, wherein the substrate surface includes a concave feature defined therein;
- and
- during the introducing, maintaining a continuous flow rate, thereby generating a layer of the nanoparticle solution at a stable concentration across the concave feature.
Dependencies are inferred from the claim text.