Biodegradable Metallic - Polymeric Composite Prosthesis for Heart Valve Replacement
AssigneesUniversity of Pittsburgh—Of the Commonwealth System of Higher Education, Ri.MED Foundation, University of Cincinnati
InventorsWilliam R. Wagner, Antonio D'Amore, Vesselin N. Shanov
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Abstract
Provided herein is a prosthetic heart valve device including a biocompatible and biodegradable metal frame comprising a proximal end, a distal end, and a sidewall therebetween, the sidewall having a plurality of openings therethrough. The device further includes a biocompatible and biodegradable polymeric heart valve having an annular portion attached at least one contact point to the proximal end of the frame and at least one leaflet attached to and extending distally from the annular portion.
Claims20
A method of manufacturing a tissue-engineered prosthetic heart valve device, the method comprising:
- photolithographically transferring a frame pattern on a metallic foil;
- chemically etching the metallic foil providing an etched foil with a shape defined by the photolithographically transferred frame pattern;
- rolling the etched foil to form a tubular support having a proximal end, a distal end, and a sidewall therebetween, the sidewall comprising a plurality of openings therethrough;
- laser-welding a seam of the tubular support;
- and
- attaching an annular portion of a polymeric heart valve, which is biocompatible and biodegradable, to a proximal end of the tubular support such that at least one leaflet of the polymeric heart valve extends from the annular portion and through an interior defined by the tubular support.
Dependencies are inferred from the claim text.