Freeze-dried nanodroplets with fluorinated compound
AssigneeBracco Suisse SA
InventorsRomain MELICH, Charles BERGER, David LAZARUS, Philippe BUSSAT, Samir CHERKAOUI
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Abstract
The present invention generally relates to the field of ultrasound contrast-agents (USCA). In particular, it relates to a freeze-dried composition comprising an amphiphilic lipid compound comprising a phospholipid, a fluorinated compound in liquid form and a freeze-drying protecting component which may be reconstituted for preparing a suspension of nanodroplets useful in diagnostic or therapeutic applications. It further relates to the method for the preparation of such freeze-dried composition.
Claims26
A freeze-dried composition comprising
- i) an amphiphilic lipid compound comprising a phospholipid,
- ii) a fluorinated compound in liquid form and
- iii) a freeze-drying protecting component
- which, upon reconstitution with a pharmaceutically acceptable liquid carrier, is capable of providing a suspension of nanodroplets comprising an inner core and an outer layer, wherein said inner core comprises said fluorinated compound in liquid form and said outer layer comprises said amphiphilic lipid compound.
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A reconstituted suspension of nanodroplets comprising a freeze-drying protecting component, said nanodroplets comprising an inner core and an outer layer, wherein said inner core comprises a fluorinated compound in liquid form and said outer layer comprises an amphiphilic lipid compound comprising a phospholipid.
Dependencies are inferred from the claim text.