Compositions and methods for virotherapy
AssigneeYeda Research and Development Co. Ltd.
InventorsMenachem RUBINSTEIN, Gideon SCHREIBER, Diana GATAULIN
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions and methods for producing target-specific therapeutic agents with improved properties, useful in oncolytic viro therapy, gene therapy, cell therapy and immunotherapy. Specifically, the invention in embodiments thereof relates to adapter molecules, capable of directing viruses and viral vectors to specific target cells ex vivo and in vivo, to methods for their preparation and use, and to therapeutic compositions comprising them.
Claims25
1-69. (canceled)
An adapter molecule, comprising an anchoring component covalently linked by a flexible linker to a targeting component, wherein:
- a. the anchoring component consists essentially of at least one isolated Class A repeat (CR) motif selected from the group consisting of:
- human low-density lipoprotein receptor (hLDLR) Class-A repeat 2 (hLDLR CR2) and hLDLR CR3, and optionally at least one of hLDLR CR1 and hLDLR CR4,
- b. the flexible linker comprises at least four contiguous amino acid residues selected from the group consisting of glycine, serine and/or alanine, and
- c. the targeting component comprises a ligand of a receptor expressed preferentially on the surface of a mammalian target cell, or an antigen-binding molecule that selectively binds the receptor.
Dependencies are inferred from the claim text.