Biomarkers and immunogenic compositions for filarial parasites
AssigneesNew York Blood Center, Inc., The United States of America as represented by the Secretary, Department of Health and Human Service
InventorsSara Lustigman, Thomas B. Nutman, Sasisekhar Bennuru
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Abstract
Disclosed herein are immunogenic compositions for preventing or treating infection with filarial parasites and biomarkers for diagnosing infection with filarial parasites.
Claims7
-27. (canceled)
A method for determining whether a subject has been infected with Dirofilaria immitis, comprising:
- (i) providing a composition comprising one or more isolated Dirofilaria immitis proteins selected from the group consisting of a protein having at least 95% sequence identity to the full length mature amino acid sequence of SEQ ID NO:
- 41, a protein having at least 95% sequence identity to SEQ ID NO:
- 49, and a protein having at least 95% sequence identity to the full length mature amino acid sequence SEQ ID NO:
- 48;
- (ii) exposing the composition to a specimen obtained from the subject;
- (iii) identifying in the specimen from the subject presence of antibodies to the one or more isolated Dirofilaria immitis proteins in the composition, wherein presence of the antibodies indicates that the subject has been infected with Dirofilaria immitis.
A composition comprising one or more isolated Dirofilaria immitis proteins selected from the group consisting of a protein having at least 95% sequence identity to the full length mature amino acid sequence of SEQ ID NO:
- 41, a protein having at least 95% sequence identity to SEQ ID NO:
- 49, and a protein having at least 95% sequence identity to the full length mature amino acid sequence SEQ ID NO:
- 48;
- and at least one epitope tag linked to the one or more isolated Dirofilaria immitis proteins.
Dependencies are inferred from the claim text.