Anticancer agent
AssigneeThe Trustees of Princeton University
InventorsMohammad R. SEYEDSAYAMDOST, Yuchen LI, Seungrak LEE, Esther J. HAN
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Abstract
Disclosed is a composition for use in treating colorectal cancer and/or adenocarcinoma. The compound may include momomycin or a derivative thereof in a pharmaceutically acceptable carrier, at a total concentration of at least 1 μM, such as 1-2 μM. The momomycin may be produced by growing a culture of a strain of Streptomyces rimosus, such as S. rimosus Δrim::aprR, in the presence of phytosphingosine. The supernatant may be filtered and purified.
Claims10
A composition for use in treating colorectal cancer and/or adenocarcinoma, comprising:
- momomycin or a derivative thereof in a pharmaceutically acceptable carrier, at a total concentration of at least 1 μM.
A pharmaceutical composition comprising:
- momomycin or a derivative thereof in a pharmaceutically acceptable carrier, at a total concentration of at least 1 μM.
A method for production of momomycin, comprising:
- growing a culture of a strain of Streptomyces rimosus in the presence of phytosphingosine.
A method for treating colorectal cancer and/or adenocarcinoma, comprising:
- administering momomycin or a derivative thereof in a pharmaceutically acceptable carrier, at a total concentration of at least 1 μM.
Dependencies are inferred from the claim text.