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US 2026/0053857 A1Published application
Compositions for Drug Delivery and Methods of Use Thereof
AssigneeStellular Bio, Inc.
InventorsJonathan N. Thon, Brad Dykstra, Brenden William Smith
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Abstract
Methods for producing megakaryoctyres and platelets derived from inducible pluripotent stem cells and comprising a therapeutic agent are provided. The present disclosure further provides methods and compositions for loading a platelet or a megakaryocyte with a therapeutic agent and for genetically modifying a platelet or a megakaryocyte to express an agent.
Claims21
-62. (canceled)
A method for preparing a lysate composition, the method comprising:
- differentiating induced pluripotent stem cells (iPSCs) into megakaryocytes;
- and
- lysing the megakaryocytes so as to obtain the lysate composition comprising one or more of Interleukin 1-beta, Interleukin 16, Interleukin 12P40, TNF-beta, BCA-1, IP-30, Fractalkine, GCkine, MCP-4, MIP-1alpha, MIP-1beta, SDF-1alpha, SDF-1beta, or a combination thereof.
A method for preparing a lysate composition, the method comprising:
- differentiating induced pluripotent stem cells (iPSCs) into megakaryocyte progenitors;
- and
- lysing the megakaryocyte progenitors so as to obtain the lysate composition comprising one or more of Interleukin 1-beta, Interleukin 16, Interleukin 12P40, TNF-beta, BCA-1, IP-30, Fractalkine, GCkine, MCP-4, MIP-1alpha, MIP-1beta, SDF-1alpha, SDF-1beta, or a combination thereof.
A composition comprising:
- a megakaryocyte lysate, wherein the megakaryocyte lysate is produced from lysing of megakaryocytes that have been differentiated from iPSCs, and wherein the megakaryocyte lysate comprises at least one factor produced during the differentiation of the iPSCs into the megakaryocytes, the at least one factor selected from Interleukin 1-beta, Interleukin 16, Interleukin 12P40, TNF-beta, BCA-1, IP-30, Fractalkine, GCkine, MCP-4, MIP-1alpha, MIP-1beta, SDF-1alpha, SDF-1beta, or a combination thereof.
Dependencies are inferred from the claim text.