Methods and compositions for treatment of amyloid-related disorders
AssigneeYale University
InventorsStephen M. STRITTMATTER, Erik Christian GUNTHER, Levi M. SMITH
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Abstract
The disclosure provides polymeric compounds that inhibit binding of an amyloid-β-oligomer to cellular prior protein, methods for identifying such compounds, and their therapeutic use. In particular, the present disclosure provides a collection of anionic polymers and methods of using these compounds to treat amyloid-related disorders, e.g., Alzheimer's disease.
Claims21
A method of treating an amyloid-related disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an anionic polymer, or a pharmaceutically acceptable salt thereof, wherein the anionic polymer comprises:
- maleic acid, or a salt thereof;
- fumaric acid, or a salt thereof;
- vinylphenylsulphuric acid, or a salt thereof;
- 2-methacryloyloxyethane sulphonic acid, or a salt thereof;
- 3-methacryloyloxy-2-hydroxypropane sulphonic acid, or a salt thereof;
- 3-methacryl amido-3-methylbutanoic acid, or a salt thereof;
- vinylphosphoric acid, or a salt thereof;
- 4-vinylbenzoic acid, or a salt thereof;
- 3-vinyl oxypropane-1-sulphonic acid, or a salt thereof;
- N-vinylsuccinimidic acid, or a salt thereof;
- poly(styrene-co-maleic acid) partial isobutyl ester, or the sodium salt thereof;
- poly(styrene-alt-maleic acid), or the sodium salt thereof;
- or
- poly(4-styrenesulfonic acid-co-maleic acid), or the sodium salt thereof.
2-6. (canceled)
16-20. (canceled)
Dependencies are inferred from the claim text.