Salts and polymorphs of a tetracycline compound
AssigneeParatek Pharmaceuticals, Inc.
InventorRaymond Cvetovich
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Abstract
Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for the treatment or prevention of conditions and disorders such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds in general.
Claims20
A crystalline form of Compound 1:
A tosylate salt of Compound 1:
A method of preparing a stable crystalline tosylate salt of Compound 1:
- wherein the method comprises:
- dissolving a freebase of Compound 1 in a first solvent or combination of solvents to form a first solution;
- dissolving p-toluenesulfonic acid in a second solvent or combination of solvents to form a second solution;
- and
- combining said first and second solution to form a third solution.
A method of treating a tetracycline responsive state in a subject in need thereof, the method comprising administering to said subject an effect amount of a crystalline form of a tosylate salt of Compound 1:
Dependencies are inferred from the claim text.