Long acting drug delivery device and its use in contraception
AssigneeBayer Aktiengesellschaft
InventorsSvante HOLMBERG, Christine TALLING
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Abstract
The invention relates to a method for altering the release characteristics of a long acting drug delivery device containing at least two drugs in different segments, wherein the segments are arranged to a specific sequence. The invention furthermore relates to a drug delivery device with reduced initial burst containing two different drugs in different segments. The invention further relates to a delivery device manufactured according to the a.m. method and its use in contraception and gynecological therapies.
Claims14
A long-acting drug-delivery device that is an implant or an intrauterine device (IUD) comprising:
- core segments that are made of silicone elastomer material and one or more of the core segments are covered with a silicone-based membrane, the core segments including:
- a first core segment including active drug A;
- a second core segment including active drug B;
- a third core segment including the active drug A;
- and
- a fourth core segment including an inactive material;
- wherein the active drug B is more soluble in the silicone elastomer material than the active drug A.
Dependencies are inferred from the claim text.