Systems and methods for analysis of microporous annealed particle scaffolds

A method for packed particle analysis, the method comprising:

• obtaining, by a computing device, labeled input data indicative of a plurality of particles positioned in a scaffold domain;
• computing, by the computing device, a void space Euclidean distance transform (EDT) for each voxel of void space of the scaffold domain, wherein the void space is defined between the plurality of particles of the labeled input data;
• determining, by the computing device, a particle configuration based on the labeled input data, wherein the particle configuration is indicative of a neighboring particle graph;
• determining, by the computing device, a plurality of medial axis landmarks based on the EDT and the particle configuration, wherein each medial axis landmark comprises a voxel of void space that is a 2D-ridge, a 1D-ridge, or a peak;
• and
• segmenting, by the computing device, the void space into a plurality of subunits based on the plurality of medial axis landmarks.