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US 2026/0049294 A1Published application
ENPP1 Polypeptides and Methods of Using Same
AssigneeYale University
InventorsPaul Stabach, Demetrios Braddock
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Abstract
The present invention includes ENPP1 polypeptides with improved in vivo half-lives.
Claims21
1-54. (canceled)
An ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) mutant polypeptide comprising an ENPP1 polypeptide which comprises at least one mutation selected from the group consisting of C101N, K103T, V105N, K445N, 1447T, P610N, V612T, R621T, P630L, E668N, R817D, and S842N as relating to SEQ ID NO:1.
Dependencies are inferred from the claim text.