Protease-cleavable moieties and methods of use thereof
AssigneeCytomX Therapeutics, Inc.
InventorsOlga VASILJEVA, Michael B. WINTER
Life of this patent
Estimating the term…
Abstract
Isolated polypeptides that include a cleavable moiety that is a substrate for at least one protease (e.g., MMP) are disclosed. Activatable molecules including the isolated polypeptides are disclosed. Methods of making and using the isolated polypeptides and activatable molecules including the isolated polypeptides in a variety of therapeutic, diagnostic, and prophylactic applications are disclosed.
Claims51
An isolated polypeptide comprising a cleavable moiety (CM) that comprises the amino acid sequence AIALY (SEQ ID NO:
- 5), wherein the CM is a substrate for a protease.
An isolated polypeptide comprising a cleavable moiety (CM) that comprises an amino acid sequence selected from SEQ ID NOs:
- 1-14, wherein the CM is a substrate for a protease.
An isolated polypeptide comprising a cleavable moiety (CM) comprising an amino acid sequence with one-amino acid or two-amino acid mutation(s) in any one of SEQ ID NOs:
- 1-14, wherein the CM is a substrate for a protease.
Dependencies are inferred from the claim text.