US 2026/0049067 A1 · CANNABINOID SYNTHESIS STARTING OUT FROM OLIVETOL AND TERPENE IN DICHLOROMETHANE WITH FeCl 3 * 6H2O AS CATALYST

Abstract

The method takes place by the reaction of olivetol with a terpene selected preferably from (+)-p-mentha-2,8-dien-1-ol, (−)-p-mentha-2,8-dien-1-ol and isopiperitenol. The reaction takes place in dichloromethane and uses FeCl3·6H2O as a catalyst. Said catalyst is added to a solution of olivetol, the mixture is kept under reflux, it is warmed to room temperature and then the terpene is added dropwise. Depending on how long the reaction is allowed to proceed from when the terpene is finished being added, cannabidiol (CBD) or tetrahydrocannabinol (THC) is obtained for longer times. The method is simple, and it gives good yields and low levels of unwanted impurities and requires an inexpensive catalyst.

Claims22

Dependent claims

A synthesis method for a cannabinoid compound that is selected from cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), comprising the steps of:

a) dissolving olivetol in dichloromethane (DCM) with stirring;
b) adding a Lewis acid as a catalyst;
c) keeping the suspension resulting from step b) under reflux for at least 20 minutes;
d) bringing the suspension obtained in c) to room temperature;
e) adding a solution of a terpene in dichloromethane dropwise and with stirring;
f) stirring for an additional 10 to 90 minutes after finishing adding the solution from e);
g) stopping the reaction;
h) purifying the synthesized cannabinoid;
wherein the catalyst added in phase b) is FeCl3·6H2O.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

19/101,202Filed 7 Aug 2023

Priority

ES P2022307305 Aug 2022

Published

19 Feb 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07D 311/80
Ring systems having three or more relevant rings: dibenzopyrans; Hydrogenated dibenzopyrans
A61K 31/658
Medicinal preparations containing organic active ingredients: o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or…
A61P 25/04
Drugs for disorders of the nervous system: centrally acting analgesics, e.g. opioids
C07C 37/16
By reactions increasing the number of carbon atoms: by condensation involving hydroxy groups of phenols or alcohols or the ether or mineral ester…

CANNABINOID SYNTHESIS STARTING OUT FROM OLIVETOL AND TERPENE IN DICHLOROMETHANE WITH FeCl 3 * 6H2O AS CATALYST

Life of this patent

CANNABINOID SYNTHESIS STARTING OUT FROM OLIVETOL AND TERPENE IN DICHLOROMETHANE WITH FeCl 3 * 6H2O AS CATALYST

Life of this patent

Abstract

Claims22