Systems and methods for mixing syringe valve assemblies and syringe formulations

A syringe coupler configured to couple to a first syringe and a second syringe, the syringe coupler comprising:

• a valve assembly having a first portion and a second portion that are displaceable relative to one another between at least a first position and a second position, wherein the first portion and the second portion comprise respective internal flow ports and syringe receiving portions, wherein the internal flow port of the first portion is configured to couple to the first syringe and the internal flow port of the second portion is configured to couple to the second syringe, wherein the second portion comprises a sealing element that is displaceable with and in fixed relative position to the second syringe, wherein the sealing element comprises an upstanding portion that defines a first sealed area that is aligned with the internal flow port of the second portion,
• wherein in the first position of the valve assembly:
• the upstanding portion of the sealing element provides a contact seal against the first portion;
• and
• the internal flow port of the second portion and the first sealed area are offset from the internal flow port of the first portion, and
• wherein in the second position of the valve assembly:
• the upstanding portion of the sealing element provides a contact seal against the first portion;
• and
• the internal flow port of the second portion and the first sealed area are aligned or substantially aligned with and in fluid communication with the internal flow port of the first portion.

A syringe-to-syringe mixing system comprising:

• a first syringe;
• a second syringe;
• a valve assembly having a first portion and a second portion that are displaceable relative to one another between at least a first position and a second position, wherein the first portion and the second portion comprise respective internal flow ports and syringe receiving portions, wherein the internal flow port of the first portion is coupled to the first syringe and the internal flow port of the second portion is coupled to the second syringe, wherein the second portion comprises a sealing element that is displaceable with and in fixed relative position to the second syringe, wherein the sealing element comprises an upstanding portion that defines a first sealed area that is aligned with the internal flow port of the second portion,
• wherein in the first position of the valve assembly:
• the upstanding portion of the sealing element provides a contact seal against the first portion;
• and
• the internal flow port of the second portion and the first sealed area are offset from the internal flow port of the first portion, and
• wherein in the second position of the valve assembly:
• the upstanding portion of the sealing element provides a contact seal against the first portion;
• and
• the internal flow port of the second portion and the first sealed area are aligned or substantially aligned with and in fluid communication with the internal flow port of the first portion to permit mixing of contents of the first and second syringes.