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US 2026/0048014 A1Published application
Methods and compositions for targeted delivery of protein fragments
AssigneeSignablok, Inc.
InventorAlexander Sigalov
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Abstract
The present invention is related to the field of targeted drug delivery. In particular, the particles and compositions described herein are used to deliver drugs to treat the diseases and conditions of interest. These particles and compositions include, but are not limited to, the lipopeptide complexes that mimic human high-density lipoproteins but contain apolipoprotein fragments or combination thereof.
Claims40
A method comprising:
- a) providing;
- i) a patient exhibiting at least one symptom of a disease or disorder;
- ii) a pharmaceutically acceptable composition comprising a reconstituted lipoprotein nanoparticle comprising:
- A) a plurality of phospholipids;
- B) at least one apolipoprotein fragment comprising a modification, wherein said modification comprises one or two sulfoxidized methionine residues and not a modified tyrosine residue;
- and
- C) at least one therapeutic agent attached to said nanoparticle;
- and
- b) administering said pharmaceutically acceptable composition to the patient such that said at least one symptom of said macrophage-associated disease or disorder is reduced.
6 more elements
A method, comprising,
- a) providing:
- i) a patient exhibiting at least one symptom of a disease or disorder;
- ii) a pharmaceutically acceptable composition comprising a reconstituted lipoprotein nanoparticle comprising:
- A) a triglyceride-cholesterol ester core surrounded by a plurality of phospholipids;
- B) at least one apolipoprotein fragment comprising a modification, wherein said modification comprises one or two sulfoxidized methionine residues and not a modified tyrosine residue;
- and
- C) at least one therapeutic agent attached to said nanoparticle;
- and
- b) administering said pharmaceutically acceptable composition to the patient such that said at least one symptom of said disease or disorder is reduced.
6 more elements
Dependencies are inferred from the claim text.