Organogels for sustained drug delivery, methods of preparation and use thereof

A sustained release, biodegradable drug-delivery system, comprising an organogel and an active agent, the organogel comprising:

• a hydrophobic organic liquid, and
• a biodegradable, covalently crosslinked polymeric network,
• wherein the hydrophobic organic liquid and the active agent are contained in the biodegradable, covalently crosslinked polymeric network, and
• wherein the biodegradable, covalently crosslinked polymeric network comprises a plurality of hydrophobic polymer units.

A method of manufacturing a sustained release, biodegradable drug-delivery system, the method comprising the steps of:

• (1) forming an organogel from at least:
• a. a covalently crosslinked polymeric network,
• b. a hydrophobic organic liquid, and
• c. at least one active agent,
• (2) wherein the hydrophobic organic liquid and the active agent are contained in the biodegradable, covalently crosslinked polymeric network,
• (3) shaping the organogel.