Nanocomposites and nanoagents for detection and treatment of a target of interest and methods of making and using same

A nanoagent for detections and treatments of multiple targets of interest, wherein each target of interest comprises a respective type of tumor cells or pathogens, comprising:

• multiple types of nanocomposites, each type of nanocomposites comprising:
• at least one nanostructure, each nanostructure having a core and a shell surrounding the core;
• a respective reporter assembled on the shell of each nanostructure;
• and
• a layer of a respective treating agent and a respective targeting agent conjugated to the respective reporter,
• wherein in use, each type of nanocomposite targets to a respective target of interest according to the respective targeting agent and releases the respective treating agent and the nanostructure therein for therapeutic treatment of the respective target of interest, and the respective target of interest transmits at least one signature responsive to the respective reporter for detection of the respective target of interest.