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AssigneeShenzhen Mindray Bio-Medical Electronics Co., Ltd.
InventorsBo LIU, Jian XIE, Gengwen CHEN, Ruixia SONG
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Provided are a method for preparing reticulocyte simulating particles and platelet simulating particles, and a reference control. The method for preparing the reticulocyte simulating particles comprises: staining mammalian anucleated red blood cells having a volume of 60-120 fL with a protein fluorescent dye activated by N-hydroxysuccinimide, and fixing the anucleated red blood cells to prepare the reticulocyte simulating particles. The platelet simulating particles are prepared from mammalian anucleated red blood cells having a volume of 2-25 fL, and the steps of preparing the platelet simulating particles are the same as that for the reticulocyte simulating particles. The preparation method comprises: using an protein fluorescent dye activated by N-hydroxysuccinimide to stain mammalian anucleated red blood cells having different volumes, so as to respectively obtain reticulocyte simulating particles and platelet simulating particles.
A cell simulating particle for a blood analyzer, wherein the cell simulating particle is a mammalian anucleated red blood cell with a surface thereof cross-linked with at least one protein fluorescent dye molecule, and wherein the at least one protein fluorescent dye molecule has an activatable carboxyl group, the surface of the mammalian anucleated red blood cell has an activatable amino group, and the amino group and the carboxyl are cross-linked via N-hydroxysuccinimide.
A method for monitoring accuracy and precision of a blood analyzer, comprising:
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