Compositions and methods for dye-bound cyclized peptides for medical use
AssigneeThe Texas A&M University System
InventorsArthur SEFIANI, Kevin BURGESS, Cedric G. GEOFFROY
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Abstract
Embodiments of the disclosure include methods and compositions related to use of compound comprising a particular peptide linked to a dye. In specific embodiments, the peptide DIRG is linked to the BODIPY dye. In specific embodiments, the compositions are utilized for treatment of neurological conditions and secondary pathologies related therewith, such as spinal cord injury and Alzheimer's Disease, as examples.
Claims40
A method of treating a neurological disorder, injury to the central or peripheral nervous system, and/or secondary pathology thereof, comprising administering to the individual a therapeutically effective amount of a composition comprising a compound of formula I:
- wherein,
- A1 and A2 are each independently H, alkyl, acyl, heterocyclyl, or aryl;
- B1, B2, B3, and B4 are each independently H or methyl;
- X1 and X2 are each independently —S—, —O—, —CH2—, or —NH—;
- R1 is
- R2 is
- R3 is
- R4 is
- M is H or alkyl;
- q is 0, 1, 2, or 3;
- Y is a dye or C4-C6 alkyl;
- and
- Z is —OH, —O-alkyl, or NA1A2, where A1 and A2 are as defined above.
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A method of improving locomotor function, improving motility, improving long-term memory, improving cognition, reducing fibrosis, and/or reducing inflammation in an individual, comprising administering to the individual a composition comprising a compound of formula I:
- wherein,
- A1 and A2 are each independently H, alkyl, acyl, heterocyclyl, or aryl;
- B1, B2, B3, and B4 are each independently H or methyl;
- X1 and X2 are each independently —S—, —O—, —CH2—, or —NH—;
- R1 is
- R2 is
- R3 is
- R4 is
- M is H or alkyl;
- q is 0, 1, 2, or 3;
- Y is a dye or C4-C6 alkyl;
- and
- Z is —OH, —O-alkyl, or NA1A2, where A1 and A2 are as defined above.
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A method of monitoring location of a compound in vivo or ex vivo comprising directly or indirectly identifying a compound comprising formula I in the individual and/or a molecule to which the compound binds:
- wherein,
- A1 and A2 are each independently H, alkyl, acyl, heterocyclyl, or aryl;
- B1, B2, B3, and B4 are each independently H or methyl;
- X1 and X2 are each independently —S—, —O—, —CH2—, or —NH—;
- R1 is
- R2 is
- R3 is
- R4 is
- M is H or alkyl;
- q is 0, 1, 2, or 3;
- Y is a dye or C4-C6 alkyl;
- and
- Z is —OH, —O-alkyl, or NA1A2, where A1 and A2 are as defined above.
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Dependencies are inferred from the claim text.