US 2026/0042787 A1 · NEW ULTRA-MICROPOROUS CRYSTALLINE METAL ORGANIC FRAMEWORKS COMPRISING BISPHOSPHONIC ACID LIGANDS

New ultra-microporous crystalline metal organic frameworks comprising bisphosphonic acid ligands

AssigneesCentre National De La Recherche Scientifique, Ecole Normale Superieure, Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris, Instituto Superior Tecnico, Faculdade De Ciencias Da Universidade De Lisboa

InventorsChristian SERRE, Antoine TISSOT, Chenchen CAO, Moisés LUZIA GONCAL VES PINTO, Joao SILVA, Fernando ANTUNES, Rosana PINTO

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Abstract

The present invention belongs to the field of nanoporous materials, in particular metal organic frameworks (MOFs) and Lewis-based gas delivery and/or slow release, or the detection of Lewis-based gas(es) in gases or liquid streams. The present invention relates, inter alia, to a new ultra-microporous crystalline metal organic framework solid (comprising bisphosphonic acid ligands (also referred to as Phosphonate MOF), such as MIP-210(M) and uses thereof as a carrier in Lewis-based gas (such as NO) delivery. The invention also relates to controlled release of the Lewis-based gas in wounds, for example by topical application. The invention also encompasses a synthetic method for producing the new ultra-microporous crystalline metal organic framework solid of the invention. The MOFs of the present invention can be used in various applications such as gas carrier and/or for the controlled release of gas. The MOFs of the present invention thus are very versatile and have therapeutic and non therapeutic applications.

Claims24

Dependent claims

An ultra-microporous crystalline metal organic framework solid comprising a three-dimensional succession of units corresponding to the following formula (I′):

wherein
M independently represents a metal selected from group consisting of Fe, Al, V, Mn, Ti, Zr and mixtures thereof, M being in oxidation state III or IV,
L represents a bisphosphonic acid ligand,
X represents an anion, optionally selected from O2-, HO—, F—, SO42-, HSO4-, H2PO4-, HPO42- or PO43-,
m is from 1 to 4, optionally m is an integer from 1 to 4,
n=0 or 1, and
y=0, 1 or 2.

4 more elements

Dependencies are inferred from the claim text.