Anaerobic Blood Storage and Pathogen Inactivation Method
AssigneeHemanext Inc.
InventorsSamuel O. SOWEMIMO-COKER, Jeffrey SUTTON, Tatsuro YOSHIDA
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Abstract
A method for reducing hemolysis and microparticle formation during storage of pathogen reduced blood. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced hemolysis. Oxygen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles. Oxygen and pathogen reduced blood compositions comprising CPAD and riboflavin having reduced hemolysis. Oxygen and pathogen reduced blood compositions comprising SAGM and riboflavin having reduced microparticles.
Claims20
-47. (canceled)
A method for reducing microparticle formation in a whole blood product comprising:
- reducing oxygen from whole blood to prepare an oxygen reduced whole blood product having an oxygen saturation (SO2) of less than 25%;
- reducing blood pathogens from the oxygen reduced blood product comprising:
- adding amustaline (S-303) to a final concentration of between 0.1 and 0.5 millimolar (mM);
- adding glutathione (GSH) to a final concentration of between 2 to 20 mM;
- and
- incubating said oxygen reduced blood product comprising the S-303 and GSH under oxygen reduced conditions for up to 9 hours to obtain an oxygen reduced pathogen reduced whole blood product,
- wherein the microparticles in the oxygen reduced pathogen reduced whole blood product are reduced by at least 10% relative to a whole blood product from which blood pathogens are reduced and oxygen is not reduced.
Dependencies are inferred from the claim text.