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US 2026/0041746 A1Published application
Transient expression system for rna, for vaccination
AssigneeGeg Tech
InventorNicolas GRANDCHAMP
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Abstract
A ribonucleic acid (RNA) or deoxyribonucleic acid (DNA) molecule, which includes an RNA Booster sequence and a sequence of interest encoding at least one antigen. Also, methods for robust transient RNA expression, in particular in the field of vaccination.
Claims21
1-14. (canceled)
A method for vaccinating a subject in need thereof, comprising administering to the subject a ribonucleic acid (RNA) or deoxyribonucleic acid (DNA) molecule comprising:
- an RNA Booster sequence comprising or consisting of the ribonucleic acid or deoxyribonucleic acid sequence mmsknkkkm or its reverse sequence mkkknksmm, wherein:
- “m” indicates an adenine (a) or cytosine (c);
- “s” indicates a guanine (g) or a cytosine (c);
- “k” indicates a guanine (g) or a uracyl/thymine (u/t);
- and
- “n” indicates any nucleotide;
- and
- a sequence of interest encoding at least one antigen.
5 more elements
Dependencies are inferred from the claim text.