Porcine collagen compositions and methods of use thereof
AssigneeOrganogenesis, Inc.
InventorsPatrick Bilbo, Katherine Faria, Bonnie Kathleen Mowry, Vivek Raut
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Abstract
The present disclosure provides compositions and methods related to wound management. The compositions include a micronized extracellular matrix and in some instances one or more antimicrobial agents. In some embodiments, the extracellular matrix is comprised of a porcine purified collagen wound matrix (CWM) and polyhexamethylene biguanide (PHMB). The composition is formulated as a powder and may be applied to a wound as a powder, or hydrated and applied to a wounds as a paste or a slurry.
Claims20
-34. (canceled)
A paste comprising sterilized micronized particles of a Collagen Wound Matrix (CWM) having a micronized average particle size of 100 to 1000 micrometers (μm) in diameter, wherein the micronized particles comprise greater than 95% (w/w) native porcine Type I collagen, and wherein the paste is for application to a wound or site of injury.
A method of manufacturing a micronized collagen composition comprising micronized particles of a Collagen Wound Matrix (CWM), the method comprising the steps of:
- generating intestinal collagen layers (ICLs) from the small intestine of a pig;
- chemically cleaning the ICLs to produce chemically-cleaned ICLs;
- drying the chemically-cleaned ICLs to produce dried, chemically-cleaned ICLs;
- and milling the dried, chemically-cleaned ICLs to produce a micronized collagen composition comprising micronized particles of a CWM,
- wherein the micronized particles have a micronized average particle size of 100 to 1000 micrometers (μm) in diameter, wherein the micronized particles comprise greater than 95% (w/w) native porcine Type I collagen, and wherein the micronized collagen composition is for application to a wound or site of injury.
Dependencies are inferred from the claim text.