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US 2026/0041729 A1Published application
Vasopressin Formulations for Use in Treatment Of Hypotension
AssigneePar Pharmaceutical, Inc.
InventorsMatthew Kenney, Vinayagam Kannan, Sunil Vandse, Suketu Sanghvi
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Abstract
Provided herein are peptide formulations comprising polymers as stabilizing agents. The peptide formulations can be more stable for prolonged periods of time at temperatures higher than room temperature when formulated with the polymers. The polymers used in the present invention can decrease the degradation of the constituent peptides of the peptide formulations.
Claims10
A method of increasing blood pressure in a human in need thereof, the method comprising treating the human with a ready-to-use pharmaceutical composition, wherein the composition comprises:
- a) between about 0.1 units/mL to about 1 unit/mL of vasopressin, or a pharmaceutically-acceptable salt thereof;
- b) dextrose, sodium chloride or combinations thereof;
- and
- c) water;
- wherein the composition is stored at a room temperature of between about 20° C. to about 25° C.;
- wherein the pH of the composition is maintained between about 3.5 to about 3.9;
- wherein the composition is storage stable for up to about 8 months.
4 more elements
Dependencies are inferred from the claim text.