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US 2026/0035689 A1Published application
Redirection of tropism of aav capsids
AssigneeVoyager Therapeutics, Inc.
InventorsMathieu E. Nonnenmacher, Jinzhao Hou, Wei Wang
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Abstract
The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.
Claims16
-15. (canceled)
A variant adeno-associated (AAV) capsid polypeptide which comprises:
- (i) the amino acid sequence of any the amino acid sequences provided in Table 2;
- (ii) the amino acid sequence of SEQ ID NO:
- 134;
- or
- (iii) the amino acid sequence of SEQ ID NO:
- 68.
3 more elements
Dependencies are inferred from the claim text.