Therapeutic nuclease compositions and methods

A polypeptide comprising a first nuclease domain, a second nuclease domain, and a human immunoglobulin Fc domain or mutant immunoglobulin Fc domain, wherein the first and second nuclease domains are operably linked, with or without a linker, to each other in series to form a tandem array, wherein the tandem array of nuclease domains is operably linked, with or without a linker, to either the C-terminus or the N-terminus of the human immunoglobulin Fc domain or mutant immunoglobulin Fc domain, wherein the first and second nuclease domains are selected from a human RNase 1 and a human DNase 1.