Compositions comprising prevascularized organoids and methods for enhancing angiogenesis
AssigneesThe Trustees of Columbia University in the City of New York, Cedars-Sinai Medical Center
InventorsSamuel K. SIA, Darragh KENNEDY, Mary Katharyn FATEHI, Dhruv SAREEN
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Abstract
Methods for producing prevascularized organoids, and compositions comprising such prevascularized organoids, are provided. Methods of treating ischemic conditions and promoting angiogenesis by administering the prevascularized organoids to a subject in need thereof are also provided.
Claims59
A method for producing prevascularized organoids, the method comprising:
- a) providing a sacrificial hydrogel scaffold;
- b) seeding a population of cells comprising endothelial cells into the sacrificial hydrogel scaffold;
- c) culturing the population of cells to form prevascularized organoids;
- and
- d) removing the sacrificial hydrogel scaffold to release the prevascularized organoids.
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An in vitro generated three-dimensional prevascularized organoid derived from a composition of cells comprising human iECs.
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Dependencies are inferred from the claim text.