Fto inhibitors

A compound of Formula (I)

• or a pharmaceutically acceptable salt thereof, a stereoisomer thereof, or a deuterated analog thereof,
• L1 is —NRa— or a single bond, wherein Ra is C1-6alkyl or C1-6alkoxy, each of said C1-6alkyl or C1-6alkoxy is unsubstituted or substituted with halogen, hydroxy, C1-6alkoxy or C1-6alkyl-S—;
• L2 is C1-6alkylene, C2-6alkenylene, C2-6alkynylene, or a single bond, wherein each of said C1-6alkylene, C2-6alkenylene, or C2-6alkynylene is unsubstituted or substituted with halogen, or hydroxy;
• L3 is a single bond, —O—, —S—, —SO—, —SO2—, —NRc—, —C(O)—, —C(O)O—, —C(O)NRc—, —OC(O)NRc—, —C(O)ONRc—, —C(O)N(Rc)O—, —OC(O)NRc—, or —NRcC(O)—;
• wherein Rc is hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, haloC1-6alkyl, hydroxyC1-6alkyl, C1-6alkoxy-C1-6alkyl, phenyl, phenylalkyl-, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl;
• R1 is hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, aryl, heteroaryl, heterocyclyl, wherein each of said C1-6alkyl, C2-6alkenyl, or C2-6alkynyl is unsubstituted or substituted with Rb, and each of said C3-8cycloalkyl, aryl, heteroaryl or heterocyclyl is unsubstituted or substituted with Rd;
• wherein
• Rb is halogen, cyano, hydroxy, C1-6alkoxy, —NRmC(O)NRnRp, —NRmC(O)Rn, —C(O)NRmRn, —NRmRn, —C(O)Rm, —C(O)ORm, C3-6cycloalkyl, phenyl, heteroaryl or heterocyclyl, wherein each of said C3-6cycloalkyl, phenyl, heteroaryl or heterocyclyl is unsubstituted or substituted with one to three substituents selected from the group consisting of cyano, halogen, C1-6alkyl, haloC1-6alkyl, hydroxy, C1-6alkoxy, haloC1-6alkoxy, C1-6alkyl-S—, C3-6cycloalkyl, phenyl, heteroaryl or heterocyclyl;
• Rd is selected from cyano, halogen, oxo, C1-6alkyl, C1-6alkoxy, hydroxy, C2-6alkenyl, C2-6alkynyl, C1-6alkyl-S—, —SF5, —NRmC(O)NRnRp, —NRmC(O)Rn, —C(O)NRmRn, —NRmRn, —C(O)Rm, —C(O)ORm, C3-8cycloalkyl, phenyl, heteroaryl or heterocyclyl, wherein said C1-6alkyl or C1-6alkoxy is unsubstituted or substituted with Re, and each of said phenyl, heteroaryl or heterocyclyl is unsubstituted or substituted with Rf,
• wherein
• Rm, Rn and Rp are each independently hydrogen, hydroxy, C1-6alkyl, haloC1-6alkyl, C1-6alkoxyC1-6alkyl-, phenyl-C1-6alkyl-, heteroaryl-C1-6alkyl-, heterocyclyl-C1-6alkyl-, heterocyclyl, heteroaryl, phenyl or naphthyl, each of said heterocyclyl, heteroaryl, phenyl or naphthyl is unsubstituted or substituted with halogen, hydroxy, oxo, C1-6alkyl, C1-6alkoxy, haloC1-6alkyl or haloC1-6alkoxy;
• Re is halogen, C1-6alkyl, C1-6alkoxy, haloalkoxy, hydroxy, —C(O)NRe1Re2, —NRe1C(O)Re2, —C(O)Re1, —ORe1, —SRe1, —NRe1Re2, heterocyclyl, heteroaryl or phenyl, each of said heterocyclyl, heteroaryl or phenyl is unsubstituted or substituted with halogen, hydroxy, C1-6alkyl, C1-6alkoxy, haloC1-6alkyl or haloC1-6alkoxy;
• wherein Re1 and Re2 are each independently hydrogen, C1-6alkyl or haloC1-6alkyl;
• Rf is halogen, C1-6alkyl, haloC1-6alkyl, C2-6alkenyl, C2-6alkynyl, hydroxy, hydroxyC1-6alkyl-, C1-6alkoxy-C1-6alkyl-, C1-6alkoxy, haloC1-6alkoxy, C1-6alkyl-S—, heterocyclyl, heteroaryl or phenyl, each of said heterocyclyl, heteroaryl or phenyl is unsubstituted or substituted with halogen, hydroxy, C1-6alkyl, C1-6alkoxy, haloC1-6alkyl or haloC1-6alkoxy;
• R2 is hydrogen, halogen, cyano, C1-6alkyl, hydroxy, or C1-6alkoxy;
• R3 is hydrogen, halogen, cyano, C1-6alkyl, hydroxy, or C1-6alkoxy;
• R4 is cyano;
• hydrogen;
• halogen;
• hydroxy;
• C1-6alkoxy;
• C1-6alkyl-S—;
• nitro (—NO2);
• or —SF5, each of said C1-6alkoxy or C1-6alkyl-S— is unsubstituted or substituted with halogen, hydroxy or C1-6alkoxy;
• or C1-6alkyl, C2-6alkenyl or C2-6alkynyl, each of said C1-6alkyl, C2-6alkenyl or C2-6alkynyl is unsubstituted or substituted with halogen, hydroxy, C1-6alkoxy or C1-6alkyl-S—;
• R5 is hydrogen, nitro (—NO2), cyano, halogen, C1-6alkyl, haloC1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, haloC1-6alkoxy, —C(O)OR5a, —SO2—R5a, or —SF5, wherein R5a is hydrogen, C1-6alkyl or haloC1-6alkyl;
• provided that if L1, L2, and L3 are each a single bond, then R1 is not hydrogen;
• further provided that the compound is not (Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-3-hydroxyacrylamide.