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US 2026/0035337 A1Published application
Triphenylphosphonium-tethered salicylamine derivatives
AssigneeMTI Biotech, Inc.
InventorsKevin Moore, Michael P. Murphy, Naji Abumrad, John Fuller, JR.
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Abstract
Novel salicylamine derivatives are targeted directly to the mitochondria to increase effectiveness and lower required dosages in the treatment of conditions caused by inflammation or oxidative stress.
Claims22
A method of treating a subject, comprising:
- administering a therapeutically effective dose of a compound of Formula I to a human or an animal subject:
- wherein:
- R1 is hydrogen with an optional counterion;
- R2 is selected from hydrogen, acyl, or alkyl, optionally substituted with R4;
- R3 is selected from hydrogen, halogen, hydroxy, acyl, alkoxy, C1-C6 alkyl optionally substituted with alkyl, alkenyl, hydroxy, acyl, or alkoxy, or carbonyl optionally substituted with hydrogen, hydroxy, acyl, C1-C2- or C3 alkyl, O, N, or S, optionally substituted with hydrogen, hydroxy, or C1-C2- or C3, alkyl, each optionally substituted with R4;
- R4 is a cation with an optional counterion;
- and
- n is 1 or 2;
- or a pharmaceutically acceptable salt thereof.
6 more elements
A method of treating a subject, comprising:
- administering a therapeutically effective dose of a compound of the following formula to a human or an animal subject:
- (5-((2-hydroxyphenyl)amino)pentyl)triphenylphosphonium bromide:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.