Transcutaneous co2 sensor and uses thereof

A sensor for transcutaneous determination of arterial CO2 partial pressure using luminescence, said sensor comprising:

• a patch assembly comprising:
• a sealing layer configured to ensure a contact between skin and the sensor;
• a CO2-permeable polymer layer configured to allow diffusion of CO2 from the skin in the patch assembly;
• a CO2-sensitive luminescent layer comprising a pH sensitive luminophore and a non-pH sensitive luminophore;
• a CO2-impermeable polymer layer embedding the CO2-sensitive luminescent layer;
• a sensing head comprising:
• a substrate;
• at least one light emitting diode configured to emit light to excite the luminophores in the CO2-sensitive luminescent layer;
• at least one photodiode configured to detect light emitted by the luminophores in the CO2-sensitive luminescent layer;
• a housing partially or totally encapsulating the substate, the at least one light emitting diode and the at least one photodiode;
• wherein the arterial CO2 partial pressure is determined by comparison of at least one luminescence property of the pH sensitive luminophore and the non-pH sensitive luminophore;
• wherein the mass ratio between the pH sensitive luminophore and the non-pH sensitive luminophore in the CO2-sensitive luminescent layer is ranging from 10% and 90%.