A method to optimise transcriptomic signatures

Abstract

The present application relates to a method of obtaining an optimised transcriptomic signature for identification of a biological condition. The optimised transcriptomic signature being optimised for detection via a particular test platform of a plurality of test platforms, each test platform being associated with at least one requirement. The method comprises receiving transcriptomic data obtained from a first set of subjects, wherein a first subset of subjects in the first set of subjects do have the biological condition, and a second subset of subjects in the first set of subjects do not have the biological condition processing the transcriptomic data to identify a plurality of candidate features, each candidate feature being suitable for use in identifying the biological condition. The method further comprises processing, based on at least one first requirement associated with a first test platform of the plurality of test platforms, the plurality of candidate features. The method further comprises outputting, based on the processing of the plurality of candidate features, the optimised transcriptomic signature for identification of a biological condition being optimised for detection via the first test platform, the optimised transcriptomic signature comprising at least one feature of the plurality of candidate features. The application also relates to a system comprising a memory for storing computer-readable instructions; and one or more processors for executing the computer readable instructions to perform the method.

Dependencies are inferred from the claim text.