Pharmaceutical Composition and Method of Isotope-Selective Modulation

A method of investigating isotopic signatures including:

• (a) Selecting at least one molecule, cell, organelle, and/or tissue of a biological organ;
• and
• (b) Determining isotopic fractionation of at least one isotope selected from the group consisting of 1H, 6Li, 12C, 10B, 14N, 16O, 17O, 24Mg, 26Mg, 28Si, 29Si, 32S, 33S, 39K, 35Cl, 40Ca, 42Ca, 43Ca, 50V, 50Cr, 52Cr, 54Fe, 56Fe, 58Ni, 60Ni, 61Ni, 63Cu, 64Zn, 66Zn, 92Mo, 94Mo, 95Mo, 96Mo, 74Se, 76Se, 77Se, 78Se, 70Ge, 72Ge, 73Ge, 79Br, 85Rb, 107Ag, 130Ba, 132Ba, 134Ba, 135Ba, and 136Ba in at least one region of the selected molecule, cell, organelle, and tissue of a biological organ.
• (c) Assessing isotopic imbalances of at least one isotope selected from the group consisting of 1H, 6Li, 12C, 10B, 14N, 16O, 17O, 24Mg, 26Mg, 28Si, 29Si, 32S, 33S, 39K, 35Cl, 40Ca, 42Ca, 43Ca, 50V, 50Cr, 52Cr, 54Fe, 56Fe, 58Ni, 60Ni, 61Ni, 63Cu, 64Zn, 66Zn, 92Mo, 94Mo, 95Mo, 96Mo, 74Se, 76Se, 77Se, 78Se, 70Ge, 72Ge, 73Ge, 79Br, 85Rb, 107Ag, 130Ba, 132Ba, 134Ba, 135Ba, and 136Ba.

A method of modulating isotopic signatures including:

• (a) Selecting at least one molecule, cell, organelle, and/or tissue of a biological organ;
• (b) Selecting at least one isotope from the group consisting of 1H, 6Li, 12C, 10B, 14N, 16O, 17O, 24Mg, 26Mg, 28Si, 29Si, 32S, 33S, 39K, 35Cl, 40Ca, 42Ca, 43Ca, 50V, 50Cr, 52Cr, 54Fe, 56Fe, 58Ni, 60Ni, 61Ni, 63Cu, 64Zn, 66Zn, 92Mo, 94Mo, 95Mo, 96Mo, 74Se, 76Se, 77Se, 78Se, 70Ge, 72Ge, 73Ge, 79Br, 85Rb, 107Ag, 130Ba, 132Ba, 134Ba, 135Ba, and 136Ba;
• (c) Enriching the selected at least one isotope to exceed its relative isotopic ratio found in a naturally occurring sample of the same chemical element, wherein said enrichment is completed on an interrelated or a singular basis;
• and
• (d) Administering the enriched selected isotope or combination of isotopes to the selected at least one molecule, cell, organelle, and/or tissue to isotopically modulate physiological processes in which said at least one molecule, cell, organelle, and/or tissue is involved.

A method of intervening with isotopic fractionation including:

• (a) Selecting at least one chemical element participating in a biological process or sequence, wherein such chemical element is selected from the group consisting of H, Li, C, B, N, O, Mg, Si, S, K, Cl, Ca, V, Cr, Fe, Ni, Cu, Zn, Mo, Se, Ge, Br, Rb, Ag, and Ba;
• (b) Determining interrelation of the selected chemical element to other chemical elements in a biological process or sequence;
• (c) Selecting at least one isotope from the group consisting of 1H, 6Li, 12C, 10B, 14N, 16O, 17O, 24Mg, 26Mg, 28Si, 29Si, 32S, 33S, 39K, 35Cl, 40Ca, 42Ca, 43Ca, 50V, 50Cr, 52Cr, 54Fe, 56Fe, 58Ni, 60Ni, 61Ni, 63Cu, 64Zn, 66Zn, 92Mo, 94Mo, 95Mo, 96Mo, 74Se, 76Se, 77Se, 78Se, 70Ge, 72Ge, 73Ge, 79Br, 85Rb, 107Ag, 130Ba, 132Ba, 134Ba, 135Ba, and 136Ba;
• (d) Enriching the selected at least one isotope to exceed its relative ratio found in naturally occurring sample of the selected chemical element;
• and
• (e) Administering a prophylactically or therapeutically effective amount of the enriched isotope to a mammal orally, rectally, nasally, intramuscularly, intravenously, parenterally, transdermally, sublingually, subcutaneously, intrathecally, buccally, and/or intravaginally, or via a combination thereof.