Type XIX Collagen Assay
AssigneeNordic Bioscience A/S
InventorsNicholas Willumsen, Jeppe Thorlacius-Ussing
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Abstract
The present invention relates to monoclonal antibodies that target collagen type XIX and to the sequences of the complementarity-determining regions distinguishing the monoclonal antibodies. Also, the present invention relates to immunoassays and to kits employing the antibodies. The assays of the invention are used in the diagnosis and monitoring of cancer.
Claims24
A monoclonal antibody that specifically recognises and binds to a peptide having the C-terminus amino acid sequence SHAHQRTGGN (SEQ ID NO:
- 1).
A method of immunoassay for detecting type XIX collagen in a human biofluid sample, said method comprising contacting a human biofluid sample with a monoclonal antibody that specifically recognises and binds to a peptide having the C-terminus amino acid sequence SHAHQRTGGN (SEQ ID NO:
- 1), and detecting binding between the monoclonal antibody and peptides in the sample.
An assay kit comprising a monoclonal antibody that specifically recognises and binds to a peptide having the C-terminus amino acid sequence SHAHQRTGGN (SEQ ID NO:
- 1), and at least one of:
- a streptavidin coated well plate;
- a N-terminal biotinylated peptide having the C-terminus amino acid sequence SHAHQRTGGN (SEQ ID NO:
- 1);
- or
- a calibrator peptide having the C-terminus amino acid sequence SHAHQRTGGN (SEQ ID NO:
- 1).
Dependencies are inferred from the claim text.