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US 2026/0028685 A1Published application
Saliva Stabilization Solution For Use In Nucleic Acid Amplification Reactions And Methods Of Use For The Detection Of Pathogen Nucleic Acids
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsSara L. Sawyer, Nicholas R. Meyerson, Qing Yang
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Abstract
In one aspect, the inventive technology relates to improved systems, methods, and compositions for a novel saliva stabilization solution for use in nucleic acid amplification reactions, and in particular embodiment its use in the detection of pathogen nucleic acids, such as SARS-CoV-2 (COVID-19).
Claims30
1-12. (canceled)
A saliva stabilization solution comprising:
- a quantity of reducing agent;
- a quantity of a chelating agent, and
- a quantity of one or more base solutions;
- a quantity of a nuclease inhibitor;
- and
- a nuclease-free water solution.
3 more elements
(canceled)
21-23. (canceled)
29-50. (canceled)
A saliva stabilization solution comprising:
- a quantity of reducing agent;
- a quantity of a chelating agent, and
- a quantity of one or more base solutions;
- a quantity of a nuclease inhibitor;
- a nuclease-free water solution;
- and
- wherein said saliva stabilization solution is combined with a saliva sample from a subject in a test having a pH-dependent readout.
4 more elements
(canceled)
59-61. (canceled)
Dependencies are inferred from the claim text.