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US 2026/0028678 A1Published application
Assessment of biological samples for nucleic acid analysis
AssigneeBelgian Volition SRL
InventorTheresa K. Kelly
Life of this patent
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Abstract
The invention relates to the measurement of cell free nucleosomes for the selection of biological samples for DNA sequencing. The invention also relates to using the measurement of cell free nucleosomes to determine the volume of body fluid sample required to obtain a required level of DNA for DNA sequencing.
Claims25
A method for the analysis of DNA in a body fluid sample, comprising:
- (a) measuring a level of nucleosomes in a body fluid sample;
- (b) determining if the level of nucleosomes measured in step (a) meets a threshold level of nucleosomes;
- (c) optionally extracting DNA from the sample if the level of nucleosomes measured in step (b) meets the threshold level of nucleosomes;
- and
- (d) sequencing DNA present in the sample if the level of nucleosomes measured in step (b) meets the threshold level.
2 more elements
A method for the analysis of DNA in a body fluid sample, comprising:
- (a) measuring a level of nucleosomes in sample obtained from a body fluid;
- (b) determining a volume of body fluid sample required to obtain a required level of DNA for DNA sequencing using the level of nucleosomes measured in step (a);
- (c) obtaining a body fluid sample of at least the volume determined in step (b);
- (d) optionally extracting DNA from the sample;
- and
- (e) sequencing the DNA present in the sample.
3 more elements
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Dependencies are inferred from the claim text.