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AssigneeFlagship Pioneering Innovations Vii, LLC
InventorsVinidhra Mani, Erica Gabrielle Weinstein, Yann Paul Guy Régis Echelard, Avak Kahvejian, Patrick Shannon Pendergrast, Tamara Ouspenskaia, Gabriel Humphrey Billings, Maxim Gerashchenko
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The disclosure provides, in various embodiments, compositions, such as polypeptides, polynucleotides, gene editing systems, small molecules, vectors or host cells, that comprise and/or modulate expression or activity of immune regulation-associated proteins, such as cytokines. The disclosure also provides, in various embodiments, methods of treating a disease or condition (e.g., a disease or condition associated with the Genome-Wide Association Study (GWAS), the Cancer Genome Atlas (TCGA), whole genome sequencing, phenome-wide association study (PheWAS), expression quantitative trait locus (cQTL) studies, or a combination thereof) using an agent that comprises and/or modulates expression or activity of an immune regulation-associated protein, and methods of identifying said agent.
An agent that comprises and/or modulates the expression or activity of a target protein comprising an amino acid sequence identified in the Sequence Listing, in Table A, or a variant thereof.
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A method of predicting a likelihood of developing a disease or condition in a subject, comprising quantifying an expression or activity of a target protein identified in the Sequence Listing, Table A, or a variant of the foregoing, in a sample from the subject, wherein the level of expression or activity of the target protein in the sample is indicative of the likelihood of developing cancer in the subject, wherein the disease or condition is associated with the Genome-Wide Association Study (GWAS), the Cancer Genome Atlas (TCGA), whole genome sequencing, phenome-wide association study (PheWAS), expression quantitative trait locus (eQTL) studies, or a combination thereof.
A method of preparing a sample that is useful for detecting a likelihood of developing a disease or condition in a subject, comprising:
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A method for identifying an agent that modulates the expression or activity of a target protein identified in the Sequence Listing, in Table A, or a variant thereof, comprising:
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Dependencies are inferred from the claim text.