Loading patent…
AssigneeMayo Foundation for Medical Education and Research
InventorsErin B. McGlinch, Joseph A. Panos, Michael A. Barry, Christopher H. Evans
Estimating the term…
This document provides methods and materials involved in promoting bone growth. For example, this document provides vectors designed to express (a) a nucleotide sequence encoding a bone morphogenetic protein 2 (BMP2) polypeptide and/or (b) a nucleotide sequence encoding an interleukin-1 receptor antagonist (IL-1Ra) polypeptide for promoting bone growth. In some cases, one or more vectors provided herein can be administered to a mammal (e.g., a human) having a disease, disorder, or condition associated with bone loss to treat the mammal. For example, a population of a single vector provided herein can be used to increase expression of a BMP2 polypeptide and an IL-1Ra polypeptide by cells within a mammal (e.g., a human) having a disease, disorder, or condition associated with bone loss to promote bone growth within the mammal.
A vector comprising a promotor sequence operably linked to a nucleic acid comprising (a) a nucleotide sequence encoding a bone morphogenetic protein (BMP) polypeptide and (b) a nucleotide sequence encoding a polypeptide that can inhibit an interleukin-1 (IL-1) polypeptide.
A method for treating a mammal having a disease, disorder, or condition associated with bone loss, wherein said method comprises administering to said mammal a vector comprising a promotor sequence operably linked to a nucleic acid comprising (a) a nucleotide sequence encoding a bone morphogenetic protein (BMP) polypeptide and (b) a nucleotide sequence encoding a polypeptide that can inhibit an interleukin-1 (IL-1) polypeptide, wherein expression of said BMP polypeptide and said polypeptide that can inhibit said IL-1 polypeptide is increased within said mammal, and wherein bone loss is reduced within said mammal or bone growth is increased within said mammal.
18-20. (canceled)
A method for promoting bone growth within a mammal, wherein said method comprises administering to said mammal a vector comprising a promotor sequence operably linked to a nucleic acid comprising (a) a nucleotide sequence encoding a bone morphogenetic protein (BMP) polypeptide and (b) a nucleotide sequence encoding a polypeptide that can inhibit an interleukin-1 (IL-1) polypeptide, wherein expression of said BMP polypeptide and said polypeptide that can inhibit said IL-1 polypeptide is increased within said mammal, and wherein bone growth is increased within said mammal.
22-26. (canceled)
A composition comprising (1) a first vector comprising nucleic acid comprising a first promotor sequence operably linked to a nucleotide sequence encoding a bone morphogenetic protein (BMP) polypeptide and (2) a second vector comprising a second promotor sequence operably linked to a nucleotide sequence encoding a polypeptide that can inhibit an interleukin-1 (IL-1) polypeptide.
(canceled)
36-47. (canceled)
A method for treating a mammal having a disease, disorder, or condition associated with bone loss, wherein said method comprises administering, to said mammal, (a) a first vector comprising nucleic acid comprising a first promotor sequence operably linked to a nucleotide sequence encoding a bone morphogenetic protein (BMP) polypeptide and (b) a second vector comprising a second promotor sequence operably linked to a nucleotide sequence encoding a polypeptide that can inhibit an interleukin-1 (IL-1) polypeptide, wherein expression of said BMP polypeptide and said polypeptide that can inhibit said IL-1 polypeptide is increased within said mammal, and wherein bone loss is reduced within said mammal or bone growth is increased within said mammal.
49-53. (canceled)
A method for promoting bone growth within a mammal, wherein said method comprises administering, to said mammal, (a) a first vector comprising nucleic acid comprising a first promotor sequence operably linked to a nucleotide sequence encoding a bone morphogenetic protein (BMP) polypeptide and (b) a second vector comprising a second promotor sequence operably linked to a nucleotide sequence encoding a polypeptide that can inhibit an interleukin-1 (IL-1) polypeptide, wherein expression of said BMP polypeptide and said polypeptide that can inhibit said IL-1 polypeptide is increased within said mammal, and wherein bone growth is increased within said mammal.
55-59. (canceled)
Dependencies are inferred from the claim text.