RNAi AGENTS OF PRION EXPRESSION

An oligomeric duplex comprising:

• a first oligomeric compound comprising a first modified oligonucleotide consisting of 23 to 30 linked nucleosides, wherein the nucleobase sequence of the first modified oligonucleotide is complementary to 23 contiguous nucleobases of:
• an equal length portion of nucleobases 839-895 of SEQ ID NO:
• 1;
• an equal length portion of nucleobases 924-980 of SEQ ID NO:
• 1;
• an equal length portion of nucleobases 1332-1371 of SEQ ID NO:
• 1;
• an equal length portion of nucleobases 1383-1507 of SEQ ID NO:
• 1;
• an equal length portion of nucleobases 1553-1660 of SEQ ID NO:
• 1;
• an equal length portion of nucleobases 1672-1711 of SEQ ID NO:
• 1;
• an equal length portion of nucleobases 1978-2034 of SEQ ID NO:
• 1;
• an equal length portion of nucleobases 2488-2586 of SEQ ID NO:
• 1;
• an equal length portion of nucleobases 2505-2586 of SEQ ID NO:
• 1;
• an equal length portion of nucleobases 2590-2790 of SEQ ID NO:
• 1;
• or
• an equal length portion of nucleobases 2624-2790 of SEQ ID NO:
• 1;
• and
• a second oligomeric compound comprising a second modified oligonucleotide consisting of 21 to 29 linked nucleosides, wherein the nucleobase sequence of the second modified oligonucleotide comprises a complementary region of at least 21 nucleobases that is at least 90% complementary to the nucleobase sequence of an equal length portion of the first modified oligonucleotide;
• and
• wherein at least one nucleoside of the first modified oligonucleotide and at least one nucleoside of the second modified oligonucleotide each independently comprises a modified sugar moiety or a modified internucleoside linkage.

An oligomeric duplex comprising:

• a first oligomeric compound comprising a first modified oligonucleotide consisting of 23 to 30 linked nucleosides, wherein the nucleobase sequence of the first modified oligonucleotide comprises the nucleobase sequence of any of SEQ ID NOs:
• 20-175;
• and
• a second oligomeric compound comprising a second modified oligonucleotide consisting of 21 to 29 linked nucleosides, wherein the nucleobase sequence of the second modified oligonucleotide comprises the nucleobase sequence of any of SEQ ID NOs:
• 176-331, wherein the nucleobase sequence of the second modified oligonucleotide is at least 90% complementary to the nucleobase sequence of an equal length portion of the first modified oligonucleotide;
• and
• wherein at least one nucleoside of the first modified oligonucleotide and at least one nucleoside of the second modified oligonucleotide each independently comprises a modified sugar moiety or a modified internucleoside linkage.