Tgfb treatment of organoid cultures to prime for regenerative therapy of damaged gi epithelia
AssigneeRutgers, The State University of New Jersey
InventorsLei CHEN, Michael P. VERZI
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Abstract
Certain emboidments provide a method of promoting regeneration of one or more intestinal stem cells in a mammalian organoid culture, the method comprising treating the organoid culture with an effective amount of transforming growth factor beta (TGFB). Certain embodiments also provide a method for preparing an organoid culture comprising intestinal stem cells and a method of treating a subject with damaged or defective intestinal tissue comprising engrafting an organoid into the subject.
Claims23
A method of promoting regeneration of one or more intestinal stem cells in a mammalian organoid culture, the method comprising treating the organoid culture with an amount of transforming growth factor beta (TGFB) effective to promote intestinal epithelial regeneration.
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